Publications

144.D. Huang, M. J. Zhang, H. y. Zhang, Z. Y. Cui, D. Luo, T. Li, X. M. Li, Y. He, S. L. Zhang, Design and synthesis of TPP+-Mitomycin C conjugate with reduced toxicity, Bioorg. Med. Chem. Lett., 2022, 77,  129036. DOI:10.1016/j.bmcl.2022.129036
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143. A. Nazli, D. L. He, D.D. Liao, M. Z. I. Khan, C. Huang, Y. He, Strategies and progresses for enhancing targeted antibiotic delivery, Adv. Drug Deliver. Rev.2022, 189, 114502. DOI: 10.1016/j.addr.2022.114502
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142. S. Zhao, Z. P. Wang, Z. Lin, G. X. Wei, X. M. Wen, S. Y. Li, X. H. Yang, Q. Zhang, C. M. Jing, Y. W. Dai, J. Guo, Y. He, Drug Repurposing by Siderophore Conjugation: Synthesis and Biological Evaluation of Siderophore-Methotrexate Conjugates as Antibiotics, Angew. Chem. Int. Ed. 134. 36 , 2022.  DOI:10.1002/ange.202204139

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141. D. Huang, Q. W. Liu, M. J. Zhang, Y. Z. Guo,Z. Y.  Cui, T.  Li, D. Luo, B. Xu,C. Huang,J. Guo, Jian. K. Y. Tam, M. Zhang, S. L. Zhang, Y. He, A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities, J. Med. Chem2022. 65. 14. 9955-9973. DOI:10.1021/acs.jmedchem.2c00640

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140. X. H. Yang, Z. P. Wang, S. C. Xiang, D. Q. Wang, Y. Zhao, D. Luo, Y. F. Qiu, C. Huang, J. Guo, Y. W. Dai, S. L. Zhang, Y. He, Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity, J. Med. Chem2022, 65. 11, 8040-8061. DOI: 10.1021/acs.jmedchem.2c00615

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139. C. P. Liu, J. X. Han, O. Marcelina, D. Nugrahaningrum, S. Huang, M. J. Zou, G. X. Wang, M. Makoto,Y. He,S. R. Wu, V. Kasim, Discovery of Salidroside-Derivated Glycoside Analogs as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia, J. Med. Chem2022, 65, 1, 135-162. DOI: 10.1021/acs.jmedchem.1c00947.

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138. H. B. Peng, B. B. Xie, J. J. Dai, Y. W. Dai, X. F. Cen, X. H. Yang, Y. He, GSH-Responsive Multifunctional Nanoparticles Based on Mannose-Modified Pillar[5]arene for Targeted Antibiotic Delivery against Intracellular MRSA. Mater. Chem. Front., 2022, 6, 360 , DOI10.1039/D1QM01459E

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137. B. B. Xie, Z. P. Wang, R. X. Zhang, Z. Zhang, Y. He, A SERS Aptasensor based on Porous Au-NC Nanoballoons for Bacteria Detection. Anal. Chim. Acta., 2022, 1190, 339175. DOI: 10.1016/j.aca.2021.339175

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136. S. Chen, Q. R. Wen, Y. Q. Zhu, Y. R. Ji, Y. Pu,Z. L. Liu, Y. He, Z. Feng, Boron-promoted reductive deoxygenation coupling reaction of sulfonyl chlorides for the C (sp3)-S bond construction. Chinese. Chem. Lett.2022, 33, 12, 5101DOI: 10.1016/j.cclet.2022.04.022

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135. Q. R. Wen, S. Chen, C. Q. Shi, S. Chen,Y. R. Ji, J. Guo,Z. L. Liu, Y. He, Z. Feng, Iron-catalyzed decarbonylative borylation enables the one-pot diversification of (Hetero) Aryl and alkyl carboxylic acids. Cell. Rep. Phys. Sci., 2022, 3, 8, 100995. DOI: 10.1016/j.xcrp.2022.100995

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134. S. Y. Li, Y. J. Wang, L. Zhong, S. Y. Wang, Z. L. Liu, Y. W. Dai, Y. He,Z. Feng, Boron-Promoted Umpolung Reaction of Sulfonyl Chlorides for the Stereospecific Synthesis of Thioglycosides via Reductive Deoxygenation Coupling Reactions. Org. Lett., 2022, 24, 13, 2463. DOI: 10.1021/acs.orglett.2c00353

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133. A. Nazli, D. He, H. C. Xu, Z. P. Wang, Y. He, A Comparative Insight on the Newly Emerging Rifamycins: Rifametane, Rifalazil, TNP-2092 and TNP-2198, Curr. Med. Chem., 2022, 29. 16. 2846 . DOI:10.2174/0929867328666210806114949

132. B. B. Xie, X. H. Yang, R. X. Zhang, J. Guo, Z. C. Chen and Y. He, Hollow and Porous Fe3C-NC Nanoballoons Nanozymes for Cancer Cell H2O2 Detection, Sens. Actuators B Chem., 2021, 347, 130579, DOI10.1016/j.snb.2021.130597

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131. H. Zhang, E. Wang, S. Geng, Z. Liu, Y. He, Q. Peng, Z. Feng, Experimental and Computational Studies of the Iron‐Catalyzed Selective and Controllable Defluorosilylation of Unactivated Aliphatic gem‐Difluoroalkenes. Angew. Chem. Int. Ed., 2021, 60, 10211-10218. DOI:10.1002/anie.202100049

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130. B. B. Xie, H. B. Peng, R. X. Zhang, C. H. Wang, Y. He,  A Label-Free Electrochemical Aptasensor Based on Stone-Like Gold Nanoparticles for Ultrasensitive Detection of Tetracycline,  J. Phys. Chem. C., 2021, 125. 5678-5683. DOI:10.1021/acs.jpcc.0c10809

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129. B. Xu, Z. P. Wang, Q. W. Liu, X. H. Yang, X. M. Li, D Huang, Y. F. Qiu, K. Y. Tam, S. L. Zhang and Y. He, Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity, Eur. J. Med. Chem., 2021, 214, 113225. DOI:10.1016/j.ejmech.2021.113225

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128. S. Y. Wang, M. H. Sun, H. Zhang, J. Zhang, Y. He, Z. Feng, Iron-Catalyzed Borylation and Silylation of Unactivated Tertiary, Secondary, and Primary Alkyl Chlorides, CCS. Chem, 2021, 3, 9, 2164. DOI:10.31635/ccschem.020.202000447

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127. H. Y. Qiu, R. P. Clausen,Y.  He, H. L. Zhu, Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research, Curr. Top. Med. Chem., 2021, 28, 21, 2593. DOI:10.2174/1568026621666210512020434

126. P. F. Wang, Y. F. Qiu, Y. He, H. L. Zhu, Cyclin-dependent kinase 4/6 inhibitors for cancer therapy: a patent review (2015–2019), Expert. Opin. Ther. Pat., 2020, 30. 795-805. DOI:10.1080/13543776.2020.1825686

125. X. H. Yang, B. B. Xie, H. B. Peng, G. M. Shi, B. Sreenivas, Y. F. Qiu, C. H. Wang, Y. He, Mannose-modified Exosomes for Targeted Delivery of Lysostaphin and Vancomycin to Eradicate Intracellular MRSA, J. Control. Release, 2020, 329, 454-467.DOI:10.1016/j.jconrel.2020.11.045

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124. H. C. Xu, A. Nazli, Z. P. Wang, Y. He, Bench-stable Imine Surrogates for the Efficient, One-pot and Catalytic Asymmetric Synthesis of α-Amino Esters/Ketones, Chem. Comm., 2020, 56, 14243-14246, DOI: 10.1039/D0CC06055K

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123.W. X. Li, S. Chen, L. F. Zhang, Y. Zhang, X. H. Yang, B. B. Xie, J. Guo, Y. He, C. H. Wang, Inhalable functional mixed-polymer microspheres to enhance doxorubicin release behavior for lung cancer treatment, Colloid Surface B., 2020111350. DOI: 10.1016/j.colsurfb.2020.111350

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122. S. Zhao, Z. P. Wang, X. M. Wen, S. Y. Li, G. X. Wei, J. Guo, Y. He, Synthesis of Vitamin B12-Antibiotic Conjugates with Improved Activity Against Gram-Negative Bacteria, Org. Lett., 2020, 16, 6632–6636DOI:10.1021/acs.orglett.0c02403QQ图片20200908083731

121. X. Zeng, Y. Zhang, Z. Liu, S. Geng, Y. He, Z. Feng, Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C–O Bonds, Org. Lett., 2020, 22, 2950-2955. DOI:10.1021/acs.orglett.0c00679

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120. S. Zhao, Z. L. Zhang, S. Y. Li, X. M. Wen, J. Guo, Y. He, Iridium-Catalyzed Cycloisomerization of N-Tethered 1,7-Enynes: Construction of Azabicyclo [5.1.0] octene System, J. Org. Chem., 202085, 9321-9330DOI:10.1021/acs.joc.0c00516

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119. S. C. Xiang, D. Huang, Q. L. He, J. Li, K. Y. Tam, S. L. Zhang, Y. He, Development of Dual Inhibitors Targeting Pyruvate Dehydrogenase Kinases and Human Iactate Dehydrogenase A: High-throughput Virtual Screening, Synthesis and Biological Validations, Eur. J. Med. Chem.2020, 1, 112579. DOI:10.1016/j.ejmech.2020.112579

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118. H. B. Peng, B. B. Xie, X. H. Yang, J. J. Dai, G. X. Wei, Y. He, Pillar[5]arene-based, Dual pH and Enzyme Responsive Supramolecular Vesicles for Targeted Antibiotic Delivery Against Intracellular MRSA, Chem. Commun., 2020, 56, 8115-8118. DOI: 10.1039/D0CC02522D

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117. B. B. Xie, H. B. Peng, C. H. Wang, Z. Zhang, Y. He, Controlled Coassembly of Dumbbell-like Au Nanoparticles with a Porous Nitrogen Doped Carbon Aerogel for Cancer Cell H2O2 Detection, Anal. Chim. Acta., 2020. 22.100-105.DOI:10.1016/j.aca.2020.06.003

Xie Beibei

116. Q. Tang, P. Hu, H. Peng, N Zhang, Q Zheng, Y. He, Near-Infrared Laser-Triggered, Self-immolative Smart Polymersomes for in Vivo Cancer TherapyInt. J. Nanome. 2020., 15, 137-149. DOI10.2147/IJN.S224502

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115. N. Zhang, P Hu, Y Wang, Q. Tang, Q. Zheng, Z. Wang, Y. He, A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Assemblyreporting FluorescenceACS sensors., 2020, 5, 319-326. DOI10.1021/acssensors.9b01093

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114. S. S. Geng, B. J. Xiong, Y Zhang, J Zhang, Y He, Z. Feng, Thiyl Radical Promoted Iron-catalyzed-selective Oxidation of Benzylic sp3 C–H Bonds with Molecular OxygenChem. Commun., 2019, 55 (84), 12699-12702. DOI: 10.1039/C9CC06584A

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113. C. L. Mao, S. Zhao, Z. L. Zang, L. Xiao, C. H. Zhou, Y. He and G. X. Cai, Pd-Catalyzed Remote Site-selective and Stereoselective C(Alkenyl)− H Alkenylation of Unactivated CycloalkenesJ. Org. Chem., 2019, 85, 774-787. DOI10.1021/acs.joc.9b02797

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112. Q. Wu, P. L. Shao, Y. He, Synthesis of 1,4,5,6-Tetrahydropyridazines and Pyridazines via Transition-Metal-Free (4+2) Cycloaddition of Alkoxyallenes with 1,2-Diaza-1,3-DienesRSC Advances., 2019, 9, 21507–21512. DOI: 10.1039/c9ra02712b

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111. L. Chandraiah, B. Sreenivas, H. Y. You, M. Tang, J. Guo, N. Qi, Y. He, The Construction of Bridged-ring-fused Naphthalenone Derivatives Through an Unexpected Zn(OTf)2-Catalyzed Cascade TransformationOrg. Lett., 2019, 21, 13, 5301-5304. DOI10.1021/acs.orglett.9b01912

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110. A. Srinivasa, B. Sreenivas, J. Jiang, N. Qi, J. Guo, Y. He, A Unified Synthetic Approach to Optically Pure Curvularin-type MetabolitesJ. Org. Chem.2019, 8411, 7227-7237. DOI: 10.1021/acs.joc.9b00776

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109. Y. Y. Liu, Z. P. Wang, S. Banne, J. Guo, Y. He, Towards the Total Synthesis of Scabrosins: Synthesis of Desulfur-scabrosins Skeleton and Its StereoisomersJ. Org. Chem., 201984, 5838-5845. DOI: 10.1021/acs.joc.9b00015

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108. Q. Liu, X. H. Yang, J. Ji, S. L. Zhang, Y. He, Novel Nannocystin A Analogues as Anticancer Therapeutics: Synthesis, Biological Evaluations and Structure-activity Relationship StudiesEur. J. Med. Chem., 2019, 170, 99-111. DOI: 10.1016/j.ejmech.2019.03.011

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107. X. H. Yang, J. S. Gao, J. Guo, Z. M. Zhao, S. L. Zhang, Y. He, Anti-lung Cancer Aactivity and Inhibitory Mechanisms of a Novel Calothrixin A Derivative, Life Sciences, 2019, 219, 20-30. DOI: 10.1016/j.lfs.2018.12.052

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106. Q. Zheng, Y. He, Q. Tang, Y. Wang, N. Zhang, J. Liu, Q. Liu, S. Zhao, P. Hu, An NIR-Guided Aggregative and Self-Immolative Nanosystem for Efficient Cancer Targeting and Combination Anticancer TherapyMol. Pharmaceutics2018, 15, 4985-4994. DOI: 10.1021/acs.molpharmaceut.8b00599

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105. N. Zhang, Y. He, Q. Tang, Y. Wang, Q. Zheng, P. Hu, A Mitochondrial Targeting Two-channel Responsive Fluorescence Probe for Imaging the Superoxide Radical Anion in Vitro and in VivoTalanta, 2019, 194, 79-85. DOI: 10.1016/j.talanta.2018.09.109

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104. X. H. Yang, G. M. Shi, J. Guo, C. H. Wang, Y. He, Exosome-Encapsulated Antibiotic Against Intracellular Infections of Methicillin-Resistant Staphylococcus Aureus (MRSA), Int. J. Nanomed., 2018, 13,  8095—8104. DOI: 10.2147/IJN.S179380

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103. N. Zhang, Z. M. Yu, X. H. Yang, Y. Zhou,J. Wang, S. L. Zhang, M. W. Wang, and Y. He, Synthesis, Biological Evaluation and Structure-activity Relationship of a Novel Class of PI3Kα H1047R Mutant Inhibitors, Eur. J. Med. Chem., 2018, 158, 707-719. DOI: 10.1016/j.ejmech.2018.09.002

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102. B. J. Xiong, X. Q. Zeng, S. S. Geng, S. Chen, B. Xu, Y. He, and Z. Feng, Thiyl Radical Promoted Chemo- and Regioselective Oxidation of C=C Bonds by Molecular Oxygen via Iron CatalysisGreen Chem., 201820, 4521-4527. DOI: 10.1039/C8GC02369G

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101. Z. P. Wang, Y. He and P. L. Shao, Transition-metal-free Synthesis of Polysubstituted Pyrrole Derivatives via Cyclization of Methyl Isocyanoacetate with Aurone Analogues, Org. Biomol. Chem., 201816, 5422-5426. DOI: 10.1039/C8OB01558A 

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100. A. Yesu, Z. M. Yu, J. Ji, C. Zou, Z. Wang, and Y. He, Tandem Diels–Alder/Oxidation–Aromatization Reactions Involving 2-Styrylchromones and ArynesOrg. Biomol. Chem., 2018, 16, 6077-6085. DOI: 10.1039/C8OB01199K

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99. N. Zhang, Z. M. Yu, X. H. Yang, Y. Zhou, Q. Tang, P. Hu, J. Wang, S. L. Zhang, M. W. Wang, and Y. He, Difuran-substituted Quinoxalines as a Novel Class of PI3K<alpha> H1047R Mutant Inhibitors: Synthesis, Biological Evaluation and Structure-activity Relationship,  Eur. J. Med. Chem., 2018, 157, 37-49. DOI: 10.1016/j.ejmech.2018.07.061

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98. Z. H. Lin, X. B. Xu, S. Zhao, X. H. Yang, J. Guo, Q. Zhang, C. M. Jing, S. Chen and Y. He, Total Synthesis and Antimicrobial Evaluation of Natural Albomycins against Clinical PathogensNat. Commun., 2018, 9, 3445. DOI: 10.1038/s41467-018-05821-1

New “Albomycin antibiotics discovered decades ago fall to total synthesis” https://cen.acs.org/pharmaceuticals/antibiotics/Albomycin-antibiotics-discovered-decades-agofall/96/web/2018/09

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97. Z. P. Wang, S. C. Xiang, P. L. Shao, Y. He, Catalytic Asymmetric [3 + 2] Cycloaddition Reaction Between Aurones and Isocyanoacetates: Access to Spiropyrrolines via Silver CatalysisJ. Org. Chem., 2018, 83, 10995-11007. DOI: 10.1021/acs.joc.8b01622

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96. B. Xu, Z. M. Yu, S. C. Xiang, Y. S. Li, S. L. Zhang, Y. He, Rational Design of Mitochondria-targeted Pyruvate Dehydrogenase Kinase 1 Inhibitors with Improved Selectivity and Antiproliferative ActivityEur. J. Med. Chem., 2018, 155 , 275-284. DOI:10.1016/j.ejmech.2018.06.012

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95. S. Li, G. M. Li, X. H. Yang, Q. Meng, S. Yuan, Y. He, D. Q. Sun, Design, Synthesis and Biological Evaluation of Artemisinin Derivatives Containing Fluorine Atoms as Anticancer AgentsBioorg. Med. Chem. Lett., 2018, 28, 2275-2278. DOI:10.1016/j.bmcl.2018.05.035

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94. S. L. Zhang, Y. He, K. Y. Tam, Targeting Cancer Metabolism to Develop Human Lactate Dehydrogenase 5 (HLDH5) InhibitorsDrug Discovery Today, 2018, 23, 1407-1415. DOI:10.1016/j.drudis.2018.05.014

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93. M. H. Zhou, Q. Su, A. Yesu, Y. He  and  Z. Wang , Asymmetric Mannich Reaction of α-Diazocarbonyl Compounds and N-sulfonyl Cyclic Ketimines Catalyzed by Complexes Generated from Chiral and Achiral Phosphines with Gold(I)Org. Biomol. Chem., 2018, 16, 2923-2931. DOI: 10.1039/C8OB00577J

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92. H. Y. You, S. Vegi, C. Lagishetti, S. Chen, R. S. Reddy, X. H. Yang, J. Guo, C. H. Wang, Y. He, Synthesis of Bioactive 3,4-Dihydro-2H-naphtho[2,3-b] [1,4]oxazine-5,10-dione and 2,3,4,5-Tetrahydro-1H-naphtho[2,3-b]azepine-6,11-dione Derivatives via Copper-catalysed Intramolecular Coupling ReactionJ. Org. Chem.2018, 83, 4119-4130. DOI:10.1021/acs.joc.8b00020

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91. N. Zhang, Z. M. Yu, X. H. Yang, P. Hu, Y. He, Synthesis of Novel Ring-contracted Artemisinin Dimers with Potent Anticancer ActivitiesEur. J. Med. Chem., 2018, 150, 829-840. DOI:10.1016/j.ejmech.2018.03.010

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90. A. Yesu, X. H. Yang, M. H. Zhou, P. R. Devi, S. L. Zhang, Z. Wang, Y. He, Synthesis and Anticancer Activity Evaluation of Novel Azacalix[2]arene[2]pyrimidinesEur. J. Med. Chem., 2018151, 214-225 DOI:  10.1016/j.ejmech.2018.02.079

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89. Z. Wang, A. Yesu, Y. He, Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with AzaheptafulvenesOrg. Lett.201820, 644–647 DOI: 10.1021/acs.orglett.7b03789

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88. Z. P. Wang; Q. Wu; J, Jiang; Z. R. Li; X. J. Peng; P. L. Shao; Y. He, Catalytic Asymmetric Synthesis of Pyrrolidine Derivatives Bearing Heteroatom-Substituted Quaternary Stereocenters, Org. Chem. Front., 20185, 36-40  DOI:10.1039/C7QO00692F

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87. Z. P. Wang, Z. R. Li; Q. Wu, X. J. Peng, P. L. Shao, Y. He, Enantioselective Synthesis of 4-Thioetherpyrrolidine Derivatives via [3 + 2] Cycloaddition of α-Thioacrylates with IsocyanoacetatesJ. Org. Chem.201782, 12869–12876  DOI:10.1021/acs.joc.7b02266

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86. Palladium-catalyzed Oxidative Arylacetoxylation of Alkenes: Synthesis of Indole and Indoline DerivativesChem. Commun., 201753, 11205-11208  DOI:10.1039/C7CC06448A

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85. P. L. Shao, Z. R. Li, Z. P. Wang, M. H Zhou, Q. Wu, P. Hu, Y. He, [3 + 2] Cycloaddition of Azaoxyallyl Cations with Cyclic Ketones: Access to Spiro-4-oxazolidinonesJ. Org. Chem.2017, 82, 10680–10686 DOI: 10.1021/acs.joc.7b01728

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84.P. R. Devi; N. Zhang; Z. M. Yu; Z. Wang; Y. He,  Total Synthesis of Kanamienamide, J. Org. Chem.2017, 82, 11262–11268. DOI: 10.1021/acs.joc.7b01984

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83. B. Sreenivas, P. R. Devi, W. X. Li, C. H. Wang, J. Guo, Y. He,  A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and GOrg. Lett.2017,19, 4996–4999. DOI: 10.1021/acs.orglett.7b02511

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82. Q. Liu, P. Hu and Y. He, Asymmetric Total Synthesis of Nannocystin AJ. Org. Chem., 201782, 9217–9222. DOI: 10.1021/acs.joc.7b01502

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81. Z. Wang; H. C. Xu; Q. Su; P. Hu; P. L. Shao; Y. He; Y. X. Lu, Enantioselective Synthesis of Tetrahydropyridines/Piperidines via Stepwise [4 + 2]/[2 + 2] CyclizationsOrg. Lett., 2017,19, 3111-3114. DOI: 10.1021/acs.orglett.7b01221

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80. M.Q. Tang; P. Hu; Q. Zheng; N. Tirelli; X. H. Yang; Z. L. Wang; Y. F. Wang; Q. Tang; Y. He, Polymeric Micelles with Dual Thermal and Reactive Oxygen Species (ROS)-Responsiveness for Inflammatory Cancer Cell DeliveryJ. Nanobiotechnology, 2017, 15, 39. DOI: 10.1186/s12951-017-0275-4

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79. Q. Zheng, P. Hu, Q. Tang, M. Q. Tang, Z. L. Zang, P. L. Shao, Z. Wang, Y. He, Dually Responsive Amphiphilic Block Copolymer with Oxidation-Responsiveness and Tuneable LCST BehavioursMater. Lett., 2017, 201,133-136. DOI: 10.1016/j.matlet.2017.05.018

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78. Z. L. Zang, S. Karnakanti, S. Zhao, P. Hu, Z. Wang, P.L. Shao, Y. He, Synthesis of Spiro-Dihydroquinoline and Octahydrophenanthrene Derivatives via Palladium-Catalyzed Intramolecular Oxidative ArylationOrg. Lett., 2017, 19, 1354-1357DOI: 10.1021/acs.orglett.7b00228

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77. X. B. Xu, Z. H. Lin, Y. Y. Liu, J. Guo. Y. He, Stevens Rearrangement of Thioethers with Arynes: A Facile Access to Multi-Substituted β-Keto ThioethersOrg. Biomol. Chem.2017,15, 2716-2720, DOI:10.1039/C7OB00277G

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76. I. N. C Kiran, R. S. Reddy, C. Lagishetti, H. C. Xu, Z. Wang, Y. He, Selective Aza Diels–Alder and Domino [4+2]/[2+2] Cycloaddition Reactions of Arynes with N-Sulfonyl Ketimines, J. Org. Chem., 2017, 82, 1823-1832. DOI: 10.1021/acs.joc.6b02667

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75. M. Q. Tang, Q. Zheng, N. Tirelli, P. Hu, Q. Tang, J. Gu, Y. HeDual Thermo/Oxidation-Responsive Block Copolymers with Self-Assembly Behaviour and Synergistic ReleaseReactive and Functional Polymers, 2017, 110, 55 –61. DOI: 10.1016/j.reactfunctpolym.2016.12.009

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6. N-H. Lin, Y. He, D. Anderson, J. Wasicak, R. Kasson, D. Sweeny, J. P. Sullivan and S. R. Arneric, “Synthesis and Structure-Activity Relationships of Pyrrolidine-Modified Analogs of Potent Cholinergic Channel Activator, ABT-418.” Bioorg. Med. Chem. Lett. 1994, 4, 2389-2392.

5. Y. He, N.-H. Lin, “Studies on Isoxazole Formation from Alkyl Carboxylic Esters.” Synthesis 1994, 989-992.

4. C.M. Lee, L.M. Jiang, H.S. Shang, P.M. Hon, Y. He, H.N.C. Wong, “Prehispanolone, a Novel Platelet Activating Factor Receptor Antagonist from Leonurus Heterophylius.Br. J. Pharmacol. 1991, 103, 1719-1724.

3. Y. He, H.M. Chang, Y.K. Lau, Y.X. Cui, R.J. Wang, T.C.W. Mak, H.N.C. Wong, C.M. Lee, “Synthesis of Diazepam Related Analogues of Miltirone, an Active Central Benzodiazepam Receptor Ligand from Salvia Miltiorrhiza Bunge (Danshen).” J. Chem. Soc. Perkin Transactions I 1990, 3359-3361.

2. Y. He, H. Zhao, X.F. Pan, S.F. Wang, “Reduction with Metal Borohydride-Transition Metal Salt System II.” Synth. Commun. 1989, 19, 3051-3054.

1. Y. He, H. Zhao, X.F. Pan, S.F. Wang, “Reduction with Metal Borohydride-Transition Metal Salt System I.” Synth. Commun. 1989, 19, 3047-3050.

Patents

76. 邹成, 周兴华, 曹蓓, 徐化成, P•K•阿加瓦尔, C•K•I•那迦, 贺耘. “N-取代恶唑酮类聚合衍生物的制备方法” 中国. CN104788396A. 2015.07.22.

75. 段方方, V•S•拉奥, 郑绍军, 游恒耀, C•拉吉施提;R•S•雷迪, 贺耘. “制备红迪菌素的三环分子骨架的方法” 中国. CN104817514A. 2015.08.05.

74. 周兴华, 王志鹏, 彭小娇, 郑绍军, 邵攀霖, 贺耘. “三嗪衍生物的不对称合成方法” 中国. CN104817560A. 2015.08.05.

73. 曹蓓, 邹成, 周兴华, 徐化成, 徐标, P·K·阿加瓦尔, C·K·I·那迦, 贺耘. “恶唑酮类杂环化合物的制备方法” 中国. CN106045935A. 2016.10.26.

72. Chen, Li; Feng, Lichun; Y, He; Huang, Mengwei; Liu, Yongfu; Yun, Hongying; Zhou, Mingwei “Preparation of novel tetrahydroquinoline derivatives as AMPK activators” WO 2012001020.

71. L. Chen, M. Huang, L. Feng, Y. He, H. Yun, “Spiro-cyclopropane-indolinone derivatives as AMPK modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases” WO2011069298

70. L. Chen, L. Feng, M. Huang, Y. He, H. Yun, “Novel cyclopropane-indolinone derivatives” US 20110144106

69. J. B. Blanc, L. Chen, F. Firooznia, P. Gillespie, R.A. Goodnow, Y. He, T.A. Lin, S.S. So, H. Yun, Z. Zhang, “Preparation of bi-aryl aminotetralines as CRTH2 receptor antagonists” WO 2010018113

68. J. B. Blanc, L. Chen, F. Firooznia, P. Gillespie, R.A. Goodnow, Y. He, T.A. Lin, S.S. So, H. Yun, Z. Zhang, “Bi-aryl aminotetralines” US 20100041714

67. L. Chen, F. Firooznia, P. Gillespie, Y. He, T.A. Lin, S.S. So, H. Yun, “Aminotetrahydroindazoloacetic acids” US 20100016368

66. L. Chen, F. Firooznia, P. Gillespie, Y. He, T.A. Lin, E. Mertz, S.S. So, H. Yun, Z. Zhang, “Preparation of naphthylacetic acids as antagonists or partial agonists at the CRTH2 receptor.” WO 2010055004

65. L. Chen, F. Firooznia, P. Gillespie, Y. He, T.A. Lin, S.S. So, H. Yun, Z. Zhang, “Preparation of 4,5,6,7-tetrahydroindazolyl acetic acids as antagonists of CRTH2 receptor” WO 2010006944

64. L. Chen, F. Firooznia, P. Gillespie, Y. He, T.A. Lin, S.S. So, H. Yun, Z. Zhang, “Aminotetrahydroindazoloacetic acids” US 8138208 (2009)

63. L. Chen, F. Firooznia, P. Gillespie, Y. He, T.A. Lin, S.S. So, H. Yun, “Aminotetrahydroindazoloacetic acids” US 8124641 (2009)

62. L. Chen, F. Firooznia, P. Gillespie, Y. He, T.A. Lin, E. Mertz, S.S. So, H. Yun, Z. Zhang, “Naphthylacetic acids” US 8124629 (2012)

61. F. Firooznia, P. Gillespie, Y. He, T.A. Lin, S.S. So, H. Yun, “Preparation of 4,5,6,7-tetrahydroindazolyl acetic acids as antagonists of CRTH2 receptor” WO 2010006939

60. L. Chen, Y. He, J.C. Wong, “Preparation of novel N-(2-aminophenyl) amide derivatives as antitumor agents” WO 2009095324

59. L. Chen, Y. He, J.C. Wong, “N-(2-amino-phenyl)-amide derivatives” US 7795315 (2009)

58. L. Chen, Y. He, J.C. Wong, “Novel N-(2-amino-phenyl)-amide derivatives” US 20090203681

57. L. Chen, X. Han, Y. He, S. Yang, Z. Zhang, “Spiroindolinone derivatives as interaction inhibitors between p53 and MDM2 proteins and their preparation, pharmaceutical compositions and use in the treatment of cancer” US 2009163512

56. T. Sim, T.N. Nguyen, B. Wu, Y. He, Y. Xie, X. Wang, G. Zhang, N.S. Gray, “Preparation of quinazolinecarboxamides as protein kinase inhibitors” US 20110053932

55. L. Chen, X. Han, Y. He, S. Yang, Z. Zhang, “Spiroindolinone derivatives” US 7776875 (2008)

54. P. Ren, X. Wang, S. Jiang, A. Nagle, B. Okram, Y. He, Y. Xie, X. Wang, S. Huang, X. Wang,  Y. Liu, P.A. Albaugh, N.S. Gray, Nathanael G. Zhang, “Preparation of pyrrolo[2,3-b]pyridinecarboxamides as protein kinase inhibitors” WO 2008144253

53. Y. He, Z. Liu, S. Huang, “Preparation of benzothiazole derivatives as protein kinase inhibitors” WO 2008124393

52.P. Ren, X. Wang, Y. He, B. Okram, X. Wang, G. Zhang, Z. Liu, Y. Liu, P.A. Albaugh, “Preparation of substituted pyrazolopyrimidinamines as protein kinase inhibitors” WO 2008112695

51. P. A. Albaugh, Y. He, S. Jiang, P. Ren, X. Wang, X. Wang, Y. Xie, “[4,5′]bipyrimidinyl-6,4′-diamine derivatives as protein kinase inhibitors” US 8026243 (2011)

50. Y. He, Z. Wang, B. Wu, “Terephthalamate compounds and compositions, and their use as HIV integrase inhibitors” US 20100016379

49. D. Chianelli, C. Cow, Y. He, S. Jiang, X. Li, X. Liu, Z. Liu, J. Loren, V. Molteni, J. Nabakka, P. Ren, T. Sim, X. Wang, S. You, “Compositions and methods for modulating c-kit and PDGFR receptors” US 7678792B2 (2010)

48. D. Chianelli, C. Cow, Y. He, S. Jiang, X. Li, X. Liu, Z. Liu, J. Loren, V. Molteni, J. Nabakka, P. Ren, T. Sim, X. Wang, S. You, “Compositions and methods for modulating c-kit and PDGFR receptors” US 20100081656

47. P. A. Albaugh, Y. He, S. Jiang, P. Ren, X. Wang, X. Wang, Y. Xie, “[4,5′]bipyrimidinyl-6,4′-diamine derivatives as protein kinase inhibitors” US 20100234376

46. P. Ren, G. Zhang, S. You, T. Sim, N. Gray, Y. Xie, X. Wang, Xing, Y. He, “Compounds and methods for FGF Receptor kinases inhibitors” US 20090312321

45. T. Marsilje, W. Lu, P. Alper, D. Mutnick, Y. He, “Preparation of indolyl or benzimidazolyl benzoic acids as TPO mimetics” US 7816542B2 (2010)

44. E.E. Swayze, Y. He, P. P. Seth, E. A. Jefferson, “Benzimidazole compounds” US 7244847 (2007)

43. P. Alper, T. Marsilje, A. Chatterjee, W. Lu, D. Mutnick, M. J. Roberts, Y. He, “Preparation of benzo[a]carbazole and indeno[1,2-b]indole derivatives as TPO mimetics” US 20090075996

42. B. Wu, T. Nguyen, D.A. Ellis, X. He, B. Anaclerio, K. Yang, H.-S. Choi, Z. Wang, T. Marsilje, Y. He, “Phenyl-substituted pyrrolidones” US 20080287516

41. Y. He, D. Woodmansee, H.-S. Choi, Z. Wang, B. Wu, T. Nguyen, “Synthesis of aryl pyrrolidones” WO 2006081562

40. HLiu, X. He, H.-S. Choi, K. Yang, D. Woodmansee, Z. Wang, D.A. Ellis, B. Wu. Y. He, T. N. Nguyen, “Preparation of pyrazolopyrimidinones and analogs, and their compositions as cannabinoid CB1 receptor inhibitors” US 20090247517

39. S, Pan, T.H. Marsilje, W. Lu, W. Gao, N.S. Gray, He, Y. Liu, Y. Mi, Y. Xie, “Immunosuppressant compounds and compositions” US 20070203100

38. H-S. Choi, Z. Wang, N.S. Gray, X.-J. Gu, X. He, Y. He, T. Jiang, Tao, Y. Liu, W. Richmond, T. Sim, K. Yang, “Compounds and compositions as protein kinase inhibitors” US 20070225306

37. H-S. Choi, Z. Wang, N.S. Gray, X.-J. Gu, X. He, Y. He, T. Jiang, Tao, Y. Liu, W. Richmond, T. Sim, K. Yang, “Substituted pyrrolo[2,3-2]pyrimidines as protein kinase inhibitors”US 7968557 (2010)

36. H. Liu, A. Chatterjee, A.; D.C. Tully, P.B. Alper, B. Bursulaya, J. Guo, D. Woodmansee, D. Mutnick, D.S. Karanewsky, Y. He, “Inhibitors of cathepsin S and pharmaceutical compositions containing cathepsin S inhibitors” US 7501408 (2009)

35. S, Pan, T.H. Marsilje, W. Lu, W. Gao, N.S. Gray, He, Y. Liu, Y. Mi, Y. Xie, “Immunosuppressant compounds and compositions” US 7572811B2 (2009)

34. H. Liu, A. Chatterjee, A.; D.C. Tully, P.B. Alper, B. Bursulaya, J. Guo, D. Woodmansee, D. Mutnick, D.S. Karanewsky, Y. He, “Inhibitors of cathepsin S and pharmaceutical compositions containing cathepsin S inhibitors” US 7314872B2 (2008)

33. V. Molteni, X. He, Y. He, A. Kreusch, J. Nabakka, K. Yang, “Bicyclic compounds and compositions as PDF inhibitors” US 7579363 (2009)

32. Y. He, E.E. Swayze, P.P. Seth, E.A. Jefferson, “Preparation of piperidinylbenzimidazoles and analogs thereof as antibacterials” WO 2004047769

31. Y. He, D.A. Ellis, B. M. Anaclerio, K.L. Kuhen, B. Wu, T. Jiang, “Quinolones with anti-HIV activity, and preparation thereof” US 7019141B2 (2006)

30. B. Wu, Y. He, T. Ngyuen, K.L. Kuhen, D.A. Ellis, T. Jiang, X. He, K. Yang, B. Bursulaya, “Pyrrolidones with anti-HIV activity” US 7495016B2 (2009)

29. B. Wu, Y. He, T. Ngyuen, K.L. Kuhen, D.A. Ellis, T. Jiang, X. He, K. Yang, B. Bursulaya, “Pyrrolidones with anti-HIV activity” US 7601742 (2009)

28. Y. He, T. Jiang, K.L. Kuhen, D.A. Ellis, B. Wu, T. Y.-H. Wu, B. Bursulaya, “Oxindoles for treatment of HIV infection, and preparation thereof” WO 2004037247

27. Y. He, Tao Jiang, Kelli L. Kuhen, David Archer Ellis, Baogen Wu, Tom Yao-Hsiang Wu, Badry Bursulaya “Oxindoles with anti-HIV activity” US 7205328 B2 (2007)

26. Y. He, Tao Jiang, Kelli L. Kuhen, David Archer Ellis, Baogen Wu, Tom Yao-Hsiang Wu, Badry Bursulaya “Oxindoles with anti-HIV activity” US 20040152755

25. E. E. Swayze, Y. He, P.P. Seth, E.A. Jefferson, “Preparation of novel benzimidazole compounds as antibacterial agents” WO 2003066622

24. K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay, “Epothilone analogs”  US 6441186B1 (2002)

23. E.E. Swayze, Y. He, P.P. Seth, E.A. Jefferson, “Benzimidazole compounds” US 7244847B2 (2007)

22. N.H. Lin, Y. He, M.W. Holladay, K.B. Ryther, Y.L. Li, H. Bai, “3-Pyridyloxymethyl heterocyclic ether compounds with nicotinic cholinergic activity, useful in controlling chemical synaptic transmission” US 6127386 (2000)

21. K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay, “Epothilone analogs”  US 6660758 (2003)

20. K.C. Nicolaou, N.P. King, M.R. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg,F. Sarabia, S. Ninkovic, D. Hepworth, T. Li, “Preparation of epothilone analogs possessing microtubule stabilizing effects and cytotoxicity” US 6380394 (2002)

19. V. Molteni, X. He, Y. He, A. Kreusch, J. Nabakka, K. Yang, “Bicyclic compounds and compositions as PDF inhibitors” US 7253164 (2007)

18. M.W. Holladay, M.A. Abreo, D.E. Gunn, N.-H. Lin, D.S. Garvey, K.B. Ryther, S.A. Lebold, R.L. Elliott, Y. He, J.T. Wasicak, H. Bai, M.J. Dart, P.P. Ehrlich, Y.L. Li, J.F. Kincaid, J.M. Schkeryantz, J.K. Lynch, “Heterocyclic Ether and Thioether Compounds Useful in Controlling Chemical Synaptic Transmission” WO 9932480

17. K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, “Epothilone Derivatives and their synthesis and use” US 20030203938

16. K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay,  M. R. Verschoyle, “Epothilone analogs” US 7173137 (2003)

15. K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, “Epothilone Derivatives and their synthesis and use” US 6531497 (2003)

14. K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, “Epothilone Derivatives and their synthesis and use” US 7579366 (2009)

13. N.H. Lin, M.W. Holladay, M.A. Abreo, D.E. Gunn, S.A. Lebold, R.L Elliott, Y. He, “Heterocyclic Ether Compounds Useful in Controlling Neurotransmitter Release” US 5914328 (1999)

12. R.L. Elliott, K.B. Ryther, M.W. Holladay, J.T. Wasicak, J.F. Daanen, N.-H. Lin, M.J. Dart, Y. He, Y. Li, “Furopyridine, Thienopyridine, Pyrrolopyridine Useful in Controlling Chemical Synaptic Transmission” US 6001849 (1999)

11. K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R.V. Finlay, “Epothilone Analogs” US 20040127432

10. N-H. Lin, Y. He, S.J. Wittenberger, “Method of Preparing Enantiomerically-Pure 3-Methyl-5-[1-alkyl-2-(S)-pyrrolidinyl]isoxazoles for Pharmaceutical use” US 5516912 (1996)

9. N-H. Lin, Y. He, S.J. Wittenberger, “Method of Preparing Enantiomerically-Pure 3-Methyl-5-[1-alkyl-2-(S)-pyrrolidinyl]isoxazoles” US 5559242 (1996)

8. M. W. Holladay, N.-H. Lin, K.B. Ryther, Y. He, “Preparation of 2-(3-Pyridyloxyalkyl)azetidines and -Pyrrolidines as Nicotinic Receptor Ligands” WO 9640682

7. N-H. Lin, Y. He, M.W. Holladay, K.B. Ryther, Y. Li, “3-Pyridyloxymethyl Heterocyclic Ether Compounds Useful as Nicotinic Cholinergic Ligands in Controlling Chemical Synaptic Transmission” US 5629325 (1997)

6. N-H. Lin, Y. He, M.W. Holladay, K.B. Ryther, H. Bai, “3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission” US 6437138 (2002)

5. N-H. Lin, Y. He, M.W. Holladay, K.B. Ryther, H. Bai, “3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission” US 6127386 (2000)

4. D. Garvey, G.M. Carrera, S. Arneric, Y.K. Shue, N.-H. Lin, Y. He, “Isoxazole and Isothiazole Compounds That Enhance Cognitive Function” WO 922133

3. N-H. Lin, Y. He, W.H. Bunnelle, “Process for the Preparation of Enantiomerically Pure 3-Methyl-5-[1-(C1-C3-Alkyl)-2-pyrrolidinyl]isoxazole” US 5508418 (1996)

2. N-H Lin, Y. He, R.L. Elliot, M.S. Chorghade, T.K. J. Esch, D.O. Beer, C.C. Witzig, C. Christian, T.C. Herzig, S.J. Wittenberger, W. H. Bunnelle, B. A. Narayanan, P. R. Singam, A. V. Rama Rao, “Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl) isoxazoles” US 5424444 (1995)

1. D. Garvey, G.M. Carrera, S. Arneric, Y.K. Shue, N.-H. Lin, Y. He, E. L. Lee, S. A. Lebold, “Isoxazole, isothiazole and pyrazole compounds that Enhance cognitive function” US 5409946 (1995)